22. IgA deficiency—hereditary aspects

Medicolegal aspects of AAGA CHAPTER 22 Jaideep

headline 22.1 Of the 141 Certain/probable and Possible cases, only 12 (11%) submitted a formal complaint to the hospital and a further 8 (6%) were reported to be involved in some legal action. Of the 17 Drug Error cases (where clearly error led to the AAGA and care was judged poor), just one patient submitted a formal complaint (6%) and one separate (6%) patient commenced legal proceedings. Of ...

New aspects of IgA synthesis in the gut.

In mammals, the gastrointestinal tract is colonized by extremely dense and diverse bacterial communities that are beneficial for health. Maintenance of the complexity and the proper localization and distribution of gut bacteria is of prime importance because when disrupted, the microbial community attacks the host's tissues and causes inflammatory reactions. Our immune system provides the neces...

IgA NEPHROPATHY: NEW ASPECTS IN PATHOPHYSIOLOGY AND PATHOGENESIS

Knowledge of the pathophysiology of immunoglobulin A nephropathy (IgAN) has progressed significantly, with this disease being clearly identified as an autoimmune disease with a peculiar autoantigen (galactosedeficient IgA1 [Gd-IgA1]), specific autoantibodies (IgG and IgA1 anti-glycans), and formation followed by mesangial deposition of circulating immune complexes with the involvement of other ...

IL 22 ( interleukin 22 )

A22 22..22

Four randomised controlled trials (RCTs) and one RCT metaanalysis are featured in the Journal this month. The latter is a review of trials of newer-generation antidepressants and cognitive–behavioural therapy (CBT) for adolescent depression (Dubicka et al, pp. 433–440). In an area of clinical practice plagued by controversy, the authors of this review were able to contribute the finding that ad...